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New Oral RA Drug Works in Unique Way

An oral rheumatoid arthritis drug called tofacitinib improved symptoms better than placebo and worked quickly in patients who had not responded to other medicines.

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Jerry Seinfeld – review

O2 Arena, London The great master of observational comedy is back. This was Jerry Seinfeld’s first show in the UK in 12 years, and he arrived in the midst of a live comedy boom in full swing: a country crazy for standup, crazy for “have you ever noticed … ?” and “what is it with … ?” – all those things of which Seinfeld is the supreme exponent. And he soon demonstrated his superb knack for hyper-inflating the implications of some absurd little detail, getting massive laughs and making it all look very, very easy. He sets the joke up in the normal conversational voice – and builds, inexorably, to the cartoon-indignant voice: a squeaky-gravelly hysterical rant in which he will briefly fling his arms around with abandon, but complete control, and never a hint that he is seriously exercised or upset about anything. Can it really be true that Jerry Seinfeld is 57 years old? This great comic still appears to have the perky buoyancy of his great TV heyday: the 1990s –that innocent era between the fall of the Berlin Wall and that of the Twin Towers sometimes known, with various levels of irony or insensitivity, as the “Seinfeld decade”, the decade about nothing. Jerry Seinfeld could have been twenty years younger, and yet he still looked a very conservative figure in his sober dark suit and pale yellow tie done all the way up to the top button. This was an old-fashioned set in many ways, and it’s not too much of a stretch to imagine Bob Newhart doing it. His best material is about being middle-aged, about not being on Facebook and not being about to “twitter” any time soon. “I could actually set up a little round mirror for me to peck at between tweets,” he snapped, peevishly, exposing his top row of teeth. Only Jerry Seinfeld could do such utterly apolitical material – “The Middle East! Are they all crazy because it’s all sand and no beach?” – without it seeming bland. He talked about his mom in Florida, and we all grinned and applauded – perhaps imagining that his imaginary Florida-dwelling mom on the TV show was in fact his real mother and that we knew all about her. Nowadays, as he indirectly acknowledged in other parts of his set, Jerry himself is getting very close to the oldster time of life. And yet the eternal thirtysomething in him lived again on stage. His gags about marriage, and marriage problems are brilliant – though they do not have the edge of real pain, even despair, that Chris Rock brings to the same subject. Incautiously, Seinfeld sets up the fantasy that marriage is like a game show in which the wife is always last week’s returning, undefeated and undefeatable champion – incautiously, because it ran the risk of reminding the audience of Seinfeld’s recent, unhappy TV show The Marriage Ref. But the gags were just so good that nobody cared. Seinfeld still has the dependable alchemy that transmutes ordinariness – or at any rate a slightly unfamiliar American ordinariness – into comedy gold. His most brilliant line is about things like restaurants or movies which are supposedly “great” yet simultaneously “suck” – and that he longs for a restaurant which is “not bad”. Perhaps his comedy has that same unshowy, inspired not-badness which is also very, very good. There will always be something enigmatic about Seinfeld: he is a comic whose heart is worn invisibly, well away from his sleeve. What does he really think? What does he really feel? Who knows? Who cares? Seinfeld is just a naturally brilliant performer, who only gets better. He is becoming the Sinatra of comedy. Rating: 4/5 Jerry Seinfeld Comedy Peter Bradshaw guardian.co.uk

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Sarah Palin’s American History Class 101

Alright, class, are we ready for our American History class, courtesy of Sarah Palin? You betcha ! It’s been at least a few seconds since we last checked in on Sarah Palin’s Tour de Grift, which stopped yesterday in Olde Boston Towne. Her bus visited such historical sights as Paul Revere’s old shack, where Palin explained the colonist’s famous “midnight ride” before the 1775 battles at Lexington and Concord. The Internet is aflame in scholarly debate over this interpretation: He who warned, uh, the British that they weren’t going to be taking away our arms uh by ringing those bells and making sure as he’s riding his horse through town to send those warning shots and bells that we were going to be secure and we were going to be free and we were going to be armed. ::facepalm:: There’s a very well known saying that history is written by the victors. Can someone please tell Sarah she’s not winning??? Can we all just breathe a collective sigh of relief that this is not the person one heartbeat away from the Oval Office? But this brings me to my current state of disgust at the breathless way she is covered by the traditional media–or the “lamestream media” as she refers to them. She cannot even recall the most dumbed-down conventional history of Revere’s claim to fame (remember ” One if by land, two if by sea? “, turning it instead into some bizarro treatise on gun rights and the inherent liberty of being armed. Not to put too fine a point on it, but this is a non-serious person. Why does the media insist on treating her otherwise? Greg Sargen t: Come on, this is just crazy. Palin is not in this race, and even if she does run, most credible observers agree that she will be a weak candidate. Just imagine this kind of thing happening with regularity on the campaign trail. The GOP establishment doesn’t want her to run. If polls are to be believed, not even her own supporters want her to run. The other day, her camp actually leaked word that she would not be meeting with party leaders in key primary states in order to encourage a sense that she’s planning an unconventional presidential campaign ! To put it mildly, that’s not exactly credible. The bus tour itself has no coherent rationale whatsoever. She launched it, transparently, after media interest in her had died down precipitously. Palin is openly mocking reporters who are treating it as real news. Until she actually declares her candidacy, mark this his whole thing down as a complete con job. I’m with Justin Elliott on this : The sight of scores of reporters chasing after Palin’s shiny new bus is one of the most dispiriting media displays we’ve seen in a very long time. Even worse, it’s happening barely days after the political media got whipsawed badly by Donald Trump’s birther hucksterism! Please make it stop.

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Qatar has sent Iman al-Obeidy back to Libya kicking and screaming, despite objections from the UN High Commissioner for Refugees. Obeidy tells CNN that Qatari guards took her and her parents from their hotel in Doha; took their cell phones, laptops, and money; beat her and handcuffed her; and then…

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Reading While Eating for June 3: Celebrating National Doughnut Day

Salute Homer Simpson’s favorite treat with today’s links. Battle of the Brands: Dunkin’ or Krispy Kreme? Both are giving out free doughnuts today. (Forbes) Crunching the Numbers: See these statistics on America’s doughnut obsession. (Huffington Post) Go-ughnut: Take a look at this life-altering doughnut transportation system. (The Daily What) The Only Thing Better Than Doughnuts:

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Seven top Republican presidential hopefuls will gather this month for the first New Hampshire 2012 debate. Mitt Romney, Tim Pawlenty, Michele Bachmann, Newt Gingrich, Herman Cain, Ron Paul, and Rick Santorum will meet at Saint Anselm College for the face-off, hosted by CNN ’s John King. It’s the first debate…

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Carey Hart

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Carey Hart

Pink Gives Birth To A Baby Girl! Congrates pink and Carey hart Dodge Motorsports / Hart and Huntington Vegas SX Finale Recap Bmartinez07 says: Congrats to Pink and Carey hart on there baby girl bet she's beautiful:)

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Say Goodbye to Those Annoying ‘Clamshell’ Plastic Containers

Well, this is a slight upside to the bad economy. The rising petroleum price could get rid of a minor health hazard: the clamshell (or oyster packaging—those plastic covers that are just impossible to take apart. The New York Times reports that in the quest to reduce cost in this tough economy, retailers are turning

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First she made a “sex tape” hawking Smartwater, now Jennifer Aniston has gone topless for the brand. In Adweek , David Kiefaber calls the new photo “topless yet modest,” but bemoans the fact that people are so excited by it: “Really, is it that surprising that she’s still attractive at 42?…

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Good news in the fight against AIDS: The annual rate of new HIV infections dropped by almost a quarter between 2001 and 2009, AIDS-related deaths have fallen, and the world has seen “unprecedented advances” in prevention and treatment accessibility, the UN AIDS agency says. Still, the unevenly-spread advancements are highly…

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