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Cancer patient receives first synthetic organ transplant

Man given synthetic trachea created by growing his own stem cells on artificial ‘scaffold’ Surgeons have performed the first transplant operation using an organ wholly grown in a laboratory to give a man a new windpipe. The 36-year-old is recovering after surgeons implanted the world’s first wholly lab-grown organ into his body. The synthetic trachea was created by growing the patient’s own stem cells on an artificial “scaffold”, which British scientists helped design. Windpipes have been grown from stem cells before, but only using the collagen “skeletons” of donated tracheas. The landmark operation at Karolinska University hospital in Sweden could mean patients may not have to wait for a suitable donor organ. This could be particularly significant for children, for whom donor tracheas are much more difficult to find. The patient, an African student living in Iceland, had been suffering from life-threatening tracheal cancer. Professor Paolo Macchiarini, a Spanish expert in regenerative medicine who led the groundbreaking operation, designed the Y-shaped synthetic trachea scaffold with Professor Alexander Seifalian, from University College London. The Y-shaped structure was made from a plastic-like “nanocomposite” polymer material consisting of microscopic building blocks. Two days after stem cells were placed into the scaffold they had grown into tracheal cells ready for transplantation. Since the organ was built from cells originating from the patient, there was no risk of it being rejected by his immune system. Prof Seifalian said: “What makes this procedure different is it’s the first time that a wholly tissue-engineered synthetic windpipe has been made and successfully transplanted, making it an important milestone for regenerative medicine. We expect there to be many more exciting applications for the novel polymers we have developed.” The patient is said to be doing well and is due to be discharged from hospital today. Medical research Stem cells Cancer Biology guardian.co.uk

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Inhofe insists he’s the victim after nearly killing airport workers

Click here to view this media Sen. James Inhofe (R-OK) is introducing legislation to create a “pilot’s bill of rights” because he feels he was unfairly treated by the Federal Aviation Administration (FAA). In October, airport construction workers told the FAA that Inhofe had endangered their lives when he landed on a runway that was clearly marked as closed. “He sky hopped over us,” airport construction supervisor Sidney Boyd told an FAA representative. “He was determined to land on that runway come hell or high water evidently.” “He come over here and started being like, ‘What the hell is this? I was supposed to have unlimited airspace,’” the construction supervisor recalled of a confrontation with Inhofe following the mishap. The FAA agreed to drop legal enforcement action in exchange for the completion of about seven hours of remedial flight training. “He almost landed a plane on a group of construction workers on a closed runway, inexplicably, but now he’s the victim,” MSNBC’s Rachel Maddow observed Wednesday. “I did nothing wrong, but at any time I could have suffered the revocation of a license,” the Oklahoma senator complained to Tulsa World .

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Cheney Mason’s “eff you” to the media probably felt pretty good at the time, but now the Casey Anthony attorney is facing a Florida Bar complaint for making the obscene gesture. A fellow attorney filed the complaint after pictures emerged of Mason flipping the bird while celebrating Anthony’s not guilty…

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News of the World to close as Rupert Murdoch acts to limit fallout

The tabloid’s 200 staff are told that Sunday’s edition will be the last, as speculation grows that it will be replaced by the Sun Rupert Murdoch acted with characteristic ruthlessness by closing the News of the World, Britain’s best-selling Sunday newspaper, in a desperate attempt to limit the political and commercial fallout from the phone-hacking affair engulfing his media empire. Murdoch’s son James, who runs his UK titles, told the paper’s 200 staff that Sunday’s edition of the paper, which sells 2.6m copies a week, would be its last, ending the 168-year history of the title his father bought in 1969, a purchase that introduced him to the British public for the first time. The last News of the World will carry no commercial advertising. “The good things the News of the World does … have been sullied by behaviour that was wrong. Indeed, if recent allegations are true, it was inhuman and has no place in our company,” he said. “The News of the World is in the business of holding others to account. But it failed when it came to itself.” There was immediate speculation last night that the paper will be replaced by a Sunday edition of the Sun which could be produced by staff at the daily. The domain names TheSunOnSunday.co.uk, TheSunOnSunday.com and SunOnSunday.co.uk were registered two days ago. Readers and retailers had reacted with disgust to the revelation this week that journalists at the News of the World ordered the private investigator Glenn Mulcaire to hack into voicemail messages left on a mobile phone belonging to murdered teenager Milly Dowler in 2002, one of the most damaging in a series of reports by the Guardian on the hacking scandal over the last two years. It also emerged that Mulcaire may have targeted the relatives of British servicemen killed in Afghanistan and Iraq and survivors of the 7/7 terrorist attacks on London. A reader boycott also seemed likely and one independent chain of newsagents said it would not stock the title. Mark Lewis, the solicitor for Milly Dowler’s family, said: “People are losing their jobs in order to sacrifice themselves to save the real perpetrators … lots of good individuals have lost their jobs or will lose their jobs and the people who should have fallen on their swords are still there.” Of Rupert Murdoch, who was filmed on a golf course during the crisis and refused to comment, Lewis added: “It’s a bit like Nero fiddling while Rome was burning.” News International’s chief executive, Rebekah Brooks, a former editor of the News of the World, was said to be in tears as news of the closure was announced. A News of the World employee who did not want to be named said Brooks had said she had offered to resign in the wake of Ed Miliband’s call for her to be sacked, but that offer had been rejected. News International denies that claim. Miliband said last night of the closure: “It’s a big act but I don’t think it solves the real issues. One of the people who’s remaining in her job is the chief executive of News International who was the editor at the time of the hacking of Milly Dowler’s phone.” Downing Street said last night: “What matters is that all wrongdoing is exposed and those responsible for these appalling acts are brought to justice.” Staff at the paper reacted with fury to the news, with one source claiming there was a “lynch mob mentality” at its London offices. Colin Myler, the editor of the News of the World, said: “Whatever price this staff are paying for past misdeeds, nothing should diminish everything this great newspaper has achieved.” The newspaper was once Murdoch’s flagship title although its stablemate, the Sun, is now more profitable, but it remained a totemic title around the world. In 1951 it sold 8.4m copies, the biggest ever circulation for any newspaper. Even now, only a handful of English-language newspapers can match its circulation. The closure followed another day of high drama, during which more companies, including O2, the mobile phone company 3, Sainsbury’s and Boots said they would not be placing adverts in the paper on Sunday. The News of the World takes about £660,000 in advertising income each weekend. James Murdoch admitted to staff it was “a matter of serious regret” that he had authorised a six-figure payment to a phone-hacking victim several years ago, but blamed others at the company for his decision. “I now know that I did not have a complete picture when I did so,” he said. “I acted on the advice of executives and lawyers.” A News of the World employee said staff suspected Murdoch had closed the title to ensure his £8bn bid to take full control of BSkyB goes through. Miliband has called for the deal to be blocked. Labour MP Tom Watson, who has been highlighting the phone-hacking scandal at the paper for two years, said: “Rupert Murdoch did not close the News of the World. It is the revulsion of families up and down the land as to what they got up to. It was going to lose all its readers and it had no advertisers left. They had no choice.” Murdoch is renowned for risk-taking and for making bold moves swiftly. But the closure of the News of the World is one of the most shocking and unexpected decisions he has made since he moved his title secretly to Wapping in east London in a successful attempt to break the print unions. It is the first closure of a national newspaper in Britain since Today was shut down, also by Murdoch, in 1995. Murdoch bought the News of the World 42 years ago after a protracted takeover battle with the late Robert Maxwell and immediately took it in a direction that many regarded as downmarket. It became the building block for his UK newspaper empire, which would in turn finance the expansion of News Corp into a global media conglomerate. News of the World Rupert Murdoch News International Phone hacking Newspapers & magazines National newspapers Newspapers James Murdoch James Robinson guardian.co.uk

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BBC under pressure to show women’s World Cup quarter-final

England’s clash with France will only be screened live via red button interactive service The BBC is under pressure from MPs and charities to show England’s quarter-final clash with France in the women’s World Cup live on one of its main channels on Saturday, amid warnings that not doing so could hamper the growth of the sport. Hope Powell’s England team, who beat Japan 2-0 earlier this week in Germany to qualify for the quarter-finals, will only be shown live via the red button interactive service. The BBC is refusing to bow to the pressure to switch it to a terrestrial channel, even though while the match is on BBC2 viewers will be watching a repeat of classic Ronnie Barker comedy Porridge and antiques show Flog It! The Women’s Sport and Fitness Foundation (WSFF), which has campaigned for more media coverage of women’s sport amid fears that a lack of female role models is leading to a precipitous drop in girls playing sport at 16, said there was a risk the game would be unable to capitalise on the surge in interest. “With the growing buzz among football fans about the World Cup quarter-final it would be an unprecedented boost for women’s sport if the BBC could find a way to rejig the schedules,” said WSFF chief executive Sue Tibballs. “We appreciate that they have existing commitments to other sports but we’re talking about the quarter-final of the World Cup – the pinnacle of women’s sport. It would send the clearest message yet to Hope Powell’s squad that the nation is backing them all the way.” The WSFF has carried out research that shows 61% of sports fans would take more interest in women’s sport if it was given a higher profile on TV. Andy Burnham, shadow education secretary, and the Tory MP Tracey Crouch, who recently raised the issue of TV coverage of the women’s World Cup in the House of Commons, took to Twitter to urge the BBC to reconsider. The BBC has said that because it is contracted to show the Scottish Open golf on BBC1, and has a longstanding policy of not showing sport on both of its main channels at the same time, it was impossible to air the match on a linear channel. Because the game kicks off at 5pm, neither BBC3 or BBC4 will be on air. “There’s a scheduling clash because we’re contracted to show the Scottish Open golf. It will be live on the red button, which is now available to 90% of the population, and there will be highlights later in the evening on BBC2,” said a BBC spokeswoman. But the highlights won’t be shown until 11.35pm and there are fears that, as a result, fewer younger viewers will end up watching the match. “Just over 1.2 million football fans tuned into watch the 2009 European Championship final and around 700,000 viewers tuned into the edited highlights of the Japan match on Tuesday, while four million people watched the game live on German TV,” said Tibballs. “It’s clear that there’s an appetite for it, and we urge the BBC to make this change.” The Football Association has recently made promotion of the women’s game a priority, after several years of criticism that it was not doing enough to back it. However, Stuart Turner, FA commercial director said: “While they’re not our rights to sell, without the BBC, these games would not be on free-to-air at all and at a time when they’re also showing Wimbledon, the British Grand Prix and The Open, there were always going to be scheduling pressures.” England’s first semi-professional women’s league, the FA Women’s Super League, began this summer. The BBC will point to its coverage across 5 Live and its website, as well as the fact that its Gabby Logan fronted live TV coverage is available to 90% of households via the red button, as evidence of its commitment. Women’s World Cup 2011 Women’s football BBC Owen Gibson guardian.co.uk

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Man loses his job after Chase bank has him arrested for cashing their own check

Click here to view this media Lynda Bryon at KING-5 News in Seattle has the story, ably summed up at The Consumerist : Ikenna [Njoku], a 28-year old construction worker, went to deposit a $8,463.21 Chase cashier’s check at his local Chase branch, only for the teller to decide that neither he nor his check looked right and he got tossed in jail for forgery, KING5 reports. The next day, a Friday, the bank realized its mistake and left a message with the detective. But it was her day off, so he spent the entire weekend in jail. By the time he got out, he had been fired from his job for not showing up to work. His car had been towed as well. It ended up getting sold off at auction because he couldn’t afford to get it out of the pound. He had been relying on that cashier’s check for his money but it was taken as evidence and by the time he got it back it was auctioned off. All this while the cashier’s check had been issued by the very bank he was trying to cash it at. Chase didn’t even apologize, not even after a year. A lawyer volunteered to help write a strongly-worded letter requesting damages. After trying hard to get a response, they sent KING 5 a two-sentence reply: “We received the letter and are reviewing the situation. We’ll be reaching out to the customer.” I dunno about you, but I have a sneaking suspicion that if he had been another color, none of this would have happened. Auburn is not a lily-white suburb by any means, but the man’s description of her questions raises all kinds of red flags. Meanwhile, I just love being at the mercy of the people who run the financial-services sector, don’t you?

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Atlantis space shuttle launch threatened by storms

Cape Canaveral downpours could postpone shuttle’s final mission by up to 10 days, warns Nasa weather expert Tropical downpours and thunderstorms around Cape Canaveral in Florida are reducing the likelihood of Nasa’s final space shuttle launching on schedule on Friday. Mission STS-135 is due to launch at 11:26am (EDT), bound for the International Space Station . But meteorologists at Nasa have warned that storm fronts will continue to hit the launch pad throughout the weekend. At a briefing on Thursday, as lightning hit the launch pad, the shuttle launch weather officer, Kathy Winters, said there was a 30% chance of favourable weather for the scheduled launch time. Winters told Spaceflight Now the weather “is not looking good for launch. As you can see outside, the clouds have rolled in, we’re starting to see some showers, we even had a thunderstorm show up this morning along Cocoa beach. We are expecting more of this the next couple of days.” And on Thursday afternoon, Nasa announced it was investigating the effects of a possible lightning strike that occurred a third of a mile from the launch pad. Engineers would review data, the agency said, and inspect the rotating service structure, which provides access to the orbiter on the launch pad and has to be rolled back before liftoff. If Atlantis misses its launch window, there are additional opportunities to launch early on Saturday and on Sunday morning, when the chances for favourable weather increase to about 40% and 60% respectively. If the delay continues after that, the next window for launch is likely to be on 16 July. A launch opportunity could also be opened up between 8 and 10 July if Nasa officials can negotiate a delay in the planned Delta IV rocket liftoff from Cape Canaveral next week. This rocket is scheduled to launch a GPS satellite. Ten hours before the scheduled launch, Nasa officials will gather to assess the latest weather forecasts before making the decision to fill Atlantis’s external fuel tanks. Technically, the team could count down to T-9 minutes before aborting, if required. Despite the potential hiccups, the STS-135 mission is technically sound and the four-person crew of Atlantis and associated ground staff are preparing to launch on time until a formal decision is made to postpone. At the weather briefing, Nasa’s test director, Jeff Spaulding, said: “Our teams here and really all around the world have been working extremely hard for quite awhile on this particular mission to make sure the vehicle and the payload are ready for hopefully a magnificent launch on Friday.” Final space shuttle mission Nasa Florida The space shuttle Space United States Alok Jha guardian.co.uk

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Atlantis space shuttle launch threatened by storms

Cape Canaveral downpours could postpone shuttle’s final mission by up to 10 days, warns Nasa weather expert Tropical downpours and thunderstorms around Cape Canaveral in Florida are reducing the likelihood of Nasa’s final space shuttle launching on schedule on Friday. Mission STS-135 is due to launch at 11:26am (EDT), bound for the International Space Station . But meteorologists at Nasa have warned that storm fronts will continue to hit the launch pad throughout the weekend. At a briefing on Thursday, as lightning hit the launch pad, the shuttle launch weather officer, Kathy Winters, said there was a 30% chance of favourable weather for the scheduled launch time. Winters told Spaceflight Now the weather “is not looking good for launch. As you can see outside, the clouds have rolled in, we’re starting to see some showers, we even had a thunderstorm show up this morning along Cocoa beach. We are expecting more of this the next couple of days.” And on Thursday afternoon, Nasa announced it was investigating the effects of a possible lightning strike that occurred a third of a mile from the launch pad. Engineers would review data, the agency said, and inspect the rotating service structure, which provides access to the orbiter on the launch pad and has to be rolled back before liftoff. If Atlantis misses its launch window, there are additional opportunities to launch early on Saturday and on Sunday morning, when the chances for favourable weather increase to about 40% and 60% respectively. If the delay continues after that, the next window for launch is likely to be on 16 July. A launch opportunity could also be opened up between 8 and 10 July if Nasa officials can negotiate a delay in the planned Delta IV rocket liftoff from Cape Canaveral next week. This rocket is scheduled to launch a GPS satellite. Ten hours before the scheduled launch, Nasa officials will gather to assess the latest weather forecasts before making the decision to fill Atlantis’s external fuel tanks. Technically, the team could count down to T-9 minutes before aborting, if required. Despite the potential hiccups, the STS-135 mission is technically sound and the four-person crew of Atlantis and associated ground staff are preparing to launch on time until a formal decision is made to postpone. At the weather briefing, Nasa’s test director, Jeff Spaulding, said: “Our teams here and really all around the world have been working extremely hard for quite awhile on this particular mission to make sure the vehicle and the payload are ready for hopefully a magnificent launch on Friday.” Final space shuttle mission Nasa Florida The space shuttle Space United States Alok Jha guardian.co.uk

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Yemen leader Saleh attacks opponents in new TV broadcast

Ali Abdullah Saleh appears on TV in broadcast from Saudi Arabia, his first public appearance since assassination attempt Yemen’s president has lashed out at opponents seeking to drive him from power in his first public appearance since he was injured in an assassination attempt last month that left him appearing stiff and weakened. Sitting rigid in a chair, his hair covered with a cloth and his hands wrapped in white bandages, Ali Abdullah Saleh accused “terrorist elements” of carrying out the 3 June attack and criticised his opponents for trying to topple him. He wore a white robe and his face appeared noticeably darker than before the attack. “Many have understood democracy incorrectly, through incorrect practices,” Saleh said in a seven-minute, pre-recorded video broadcast on Yemen state TV from Saudi Arabia, where he is receiving treatment. Saleh said he has undergone more than eight “successful operations,” adding to speculation about the severity of his injuries. Without naming any particular parties or groups, he called for dialogue as the only way to end the country’s crisis. “Where are the conscious people? Where are the honest people? Where are the believers and the men who fear Allah? Why don’t they stand with dialogue?” he said. “They should stand with dialogue so we can find solutions.” More than four months of popular uprising seeking to push the longtime ruler from power have shaken the impoverished corner of the Arabian Peninsula. Saleh has been in treatment in Saudi Arabia since 5 June after being injured in a bomb attack at his palace compound. Yemen Middle East Arab and Middle East unrest guardian.co.uk

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Harry Potter and the Deathly Hallows: Part 2 – review

Sensational, satisfying, surreal … an explosive final chapter puts the magic back into the Harry Potter franchise. WARNING: CONTAINS SPOILERS “It all ends,” says the poster slogan. A potentially grim statement of the obvious, of course, yet the Potter saga could hardly have ended on a better note. With one miraculous flourish of its wand, the franchise has restored the essential magic to the Potter legend – which had been starting to sag and drift in recent movies – zapping us all with a cracking final chapter, which looks far superior to CS Lewis’s The Last Battle or JRR Tolkien’s The Return of the King . It’s dramatically satisfying, spectacular and terrifically exciting, easily justifying the decision to split the last book into two. Here is where the Harry Potter series gets its groove back, with a final confrontation between Voldemort (Ralph Fiennes) and our young hero, and with the sensational revelation of Harry’s destiny, which Dumbledore had been keeping secret from him. When stout-hearted young Neville Longbottom (a scene-stealer from Matthew Lewis) steps forward to denounce the dark lord in the final courtyard scene, I was on the edge of my seat. And when, in that final “coda”, the middle-age Harry Potter gently hugs his little boy before sending him off for his first term at Hogwarts – well, what can I say? I think I must have had something in my eye. The colossal achievement of this series really is something to wonder at. The Harry Potter movies showed us their characters growing older in real time: unlike Just William or Bart Simpson, Daniel Radcliffe’s Harry was going to grow up like a normal person and never before has any film – or any book – brought home to me how terribly brief childhood is. The Potter movies weren’t just an adaptation of a series of books, but a living, evolving collaborative phenomenon between page and screen. The first movie, Philosopher’s Stone , came out in 2001, when JK Rowling was working on the fifth book, Order of the Phoenix , and when no one – perhaps not even the author herself – knew precisely how it was going to end. The movies developed just behind the books, and it’s surely impossible to read them without being influenced by the films. This is most true for Robbie Coltrane’s endlessly lovable, definitive performance as Hagrid . In this final episode, Harry (Radcliffe), Hermione ( Emma Watson ) and Ron ( Rupert Grint ) continue their battle to find and destroy the “horcruxes” that the sinister Voldemort needs so he can stay alive for all eternity: these are objects in which the fragments of souls are trapped and whose vital, spiritual force Voldemort, that hateful parasite, can siphon off for his own ends. Harry and his friends track down these horcruxes, but the last one is a puzzle. As the forces of good assemble at Hogwarts for the final showdown with Voldemort and his hordes, Harry knows only that the most vital horcrux is actually in the castle, very close at hand. There are some superb set-piece scenes – and now the plot has so much more zing, these scenes have a power that comparable moments in earlier movies did not have. When Harry, Ron and Hermione insinuate themselves into Gringotts Bank to steal the sword of Gryffindor, the effect is bizarre, surreal and macabre: drawing on the influence of Lewis Carroll and Terry Gilliam. It is a great moment when Severus Snape , played with magnificently adenoidal disdain by Alan Rickman, is attacked by Voldemort’s snake Nagini, and we witness this only from behind a frosted glass screen – a nice touch from director David Yates . London-dwelling Potter fans will, as before, be intrigued to see how the ornate St Pancras railway station is used to represent King’s Cross, from where the Hogwarts train traditionally departs. Millions of tourists are undoubtedly convinced that this building is, in fact, King’s Cross. It may be forced simply to change its name. We get passionate, but somehow touchingly innocent screen kisses between Harry and Ginny (Bonnie Wright) and, of course, between Ron and Hermione. In the midst of the battle, Neville declares that he is going to find Luna (Evanna Lynch) for a snog: “I’m mad about her! About time I told her, since we’re both probably going to be dead by dawn!” But these love stories are always subordinate to the all-important battle between good and evil. The crucial moment of the film is where, I admit, I have a quibble: it is gripping and even moving when Harry realises what his destiny is, and sets out to fulfil it. Yet the exact rationale for his ultimate survival may be a little obscure, and perhaps even Potter-diehards may suspect that in the film there is a touch of having your cake and eating it. Well, no matter. This is such an entertaining, beguiling, charming and exciting picture. It reminded me of the thrill I felt on seeing the very first one, 10 years ago. And Radcliffe’s Harry Potter has emerged as a complex, confident, vulnerable, courageous character – most likable, sadly, at the point where we must leave him for ever. Wait. I’ve got that darn thing in my eye again … Rating: 4/5 Harry Potter Daniel Radcliffe Emma Watson Rupert Grint Ralph Fiennes Science fiction and fantasy Action and adventure Harry Potter JK Rowling Peter Bradshaw guardian.co.uk

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